Table 1. EGFR mutations detected by MALDI-TOF MS.
Mutation type | Cases (n) | Percent |
---|---|---|
Screened cases | 1,354 | |
EGFR mutant cases | 171/1,354 | 12.6 |
Activating mutations | 163/171 | 95.3 |
Single mutation | ||
E709K | 1 | 0.6 |
G719C | 3 | 1.8 |
Exon 19 del | 104 | 63.8 |
L858R | 42 | 25.8 |
L861Q | 6 | 3.7 |
Concurrent mutations | ||
G719A, L861Q | 1 | 0.6 |
G719A, S768I | 1 | 0.6 |
Exon 19 del, T790M | 1 | 0.6 |
Exon 19 del, S768I | 1 | 0.6 |
L858R, I744M | 1 | 0.6 |
L858R, T790M | 1 | 0.6 |
L858R, S768I | 1 | 0.6 |
Exon 20 mutations | 8/171 | 4.8 |
T790M | 1 | 0.6 |
S768I | 1 | 0.6 |
Ins exon 20 | 6 | 3.5 |