Table 3. Subgroup analysis for OS and RFS.
| Subgroup | Overall survival, median (95% CI) | P value for whole2 | RFS, median (95% CI) | P value for whole |
|---|---|---|---|---|
| TIM3TILs expression1 | 0.154 | 0.022 | ||
| A: positive | 1.11 (0.32, 1.90) | 0.87 (0.20, 1.53) | ||
| B: negative | 2.96 (2.28, 3.64) | 1.82 (0.81, 2.82) | ||
| GAL-9tumor expression | 0.039 | 0.083 | ||
| A: positive | 3.10 (2.66, 2.53) | 2.72 (1.40, 4.03) | ||
| B: negative | 1.69 (0.28, 3.10) | 1.21 (0.49, 1.92) | ||
| GAL-9LTILs expression | 0.4 | 0.036 | ||
| A: positive | 1.08 (0.01, 2.27) | 0.67 (0.08, 1.25) | ||
| B: negative | 2.79 (1.96, 3.62) | 1.80 (0.83, 2.76) | ||
| OX40tumors expression | 0.097 | 0.075 | ||
| A: positive | – | – | ||
| B: negative | 2.77 (1.67, 3.87) | 1.48 (0.89, 2.06) | ||
| OX40TILs expression | 0.380 | 0.155 | ||
| A: positive | 1.74 (0.42, 3.05) | 1.42 (1.06, 1.77) | ||
| B: negative | 3.01 (2.18, 3.83) | 2.09 (0.92, 3.25) | ||
| OX40Ltumors expression | 0.027 | 0.066 | ||
| A: positive | 1.08 (0.30, 1.85) | 0.89 (0.18, 1.59) | ||
| B: negative | 3.04 (2.31, 3.76) | 1.91 (0.97, 2.84) | ||
| OX40LTILs expression | 0.221 | 0.077 | ||
| A: positive | 2.14 (0.91, 3.36) | 1.42 (0.86, 1.97) | ||
| B: negative | 3.23 (2.88, 3.57) | 3.19 (2.27, 3.58) | ||
| TILs condition | 0.568 | 0.715 | ||
| A: positive | 2.78 (1.69, 3.86) | 1.69 (1.29, 2.08) | ||
| B: negative | 2.31 (0.64, 3.97) | 1.90 (0.11, 3.68) | ||
| LAG3 expression | 0.039 | 0.025 | ||
| A: positive | 1.08 (0.41, 1.74) | 0.87 (0.26, 1.47) | ||
| B: negative | 3.04 (2.76, 3.31) | 1.91 (0.76, 3.05) | ||
| PD-1 expression | 0.558 | 0.881 | ||
| A: positive | 2.97 (1.35, 4.58) | 1.47 (0.58, 2.35) | ||
| B: negative | 2.29 (1.04, 3.53) | 1.76 (1.27, 2.24) | ||
| PD-L1tumor expression | 0.29 | 0.054 | ||
| A: positive | 1.29 (0.62, 1.95) | 0.97 (0.70, 1.23) | ||
| B: negative | 2.96 (2.25, 3.66) | 1.85 (0.76, 2.93) | ||
| PD-L1TILs expression | 0.198 | 0.53 | ||
| A: positive | 3.09 (2.52, 3.65) | 1.76 (0.39, 3.48) | ||
| B: negative | 2.09 (0.74, 3.43) | 1.48 (0.71, 2.25) | ||
| MHCIItumors expression | 0.083 | 0.642 | ||
| A: positive | 3.03 (2.66, 3.40) | 1.91 (0.54, 3.27) | ||
| B: negative | 2.09 (0.82, 3.53) | 1.47 (0.84, 2.09) | ||
| MHCIITILs expression | 0.028 | 0.014 | ||
| A: positive | 2.98 (1.68, 4.33) | 3.23 (2.61, 3.84) | ||
| B: negative | 1.05 (0.55, 1.54) | 1.39 (0.62, 2.15) |
1, TIM3tumor is excluded due to lack of sufficient subgroup sample size; 2, intergroup comparison used Log-rank analysis to determine the differences.