Table 4.
Average Closed-loop Results for all the In Silico Adults With the Multistage Model Predictive Control and Regular Model Predictive Control Strategies.
| MS-MPC |
rMPC |
|||||
|---|---|---|---|---|---|---|
| Mean | Median | IQR | Mean | Median | IQR | |
| Overall | ||||||
| Average blood glucose (mg/dL) | 144.7 | 142.5 | 16.6 | 136.6 | 135.3 | 19.0 |
| Max blood glucose (mg/dL) | 239.9 | 235.5 | 42.3 | 206.4 | 205.5 | 50.1 |
| Min blood glucose (mg/dL) | 80.7 | 82.4 | 22.0 | 68.2 | 65.8 | 13.6 |
| % time > 250 mg/dL | 1.66 | 0.00 | 2.34 | 0.52 | 0.00 | 0.00 |
| % time > 180 mg/dL | 18.56 | 16.10 | 15.71 | 13.66 | 11.69 | 20.26 |
| % time in [70-180] mg/dL | 81.16 | 83.90 | 16.49 | 85.56 | 87.92 | 20.26 |
| % time in [70-140] mg/dL | 54.62 | 54.55 | 21.56 | 60.38 | 58.70 | 22.99 |
| % time < 70 mg/dL | 0.28 | 0.00 | 0.52 | 0.77 | 0.78 | 1.04 |
| % time < 54 mg/dL | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LBGI | 0.19 | 0.18 | 0.20 | 0.36 | 0.35 | 0.21 |
| HBGI | 3.90 | 3.44 | 2.84 | 2.94 | 2.68 | 2.63 |
| Total daily insulin (U/d) | 36.0 | 34.0 | 10.8 | 37.4 | 35.0 | 11.6 |
| # hypo treats during exercise | 8 | 68 | ||||
| Exercise | ||||||
| Average blood glucose (mg/dL) | 119.7 | 117.8 | 27.7 | 96.3 | 92.5 | 18.6 |
| Max blood glucose (mg/dL) | 137.0 | 131.8 | 29.8 | 122.3 | 115.0 | 27.5 |
| Min blood glucose (mg/dL) | 104.5 | 105.0 | 29.8 | 72.9 | 67.7 | 21.6 |
| % time > 250 mg/dL | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| % time > 180 mg/dL | 2.6 | 0.0 | 0.0 | 0.5 | 0.0 | 0.0 |
| % time in [70-180] mg/dL | 96.2 | 100 | 0.0 | 86.7 | 84.6 | 23.1 |
| % time in [70-140] mg/dL | 80.5 | 100 | 30.8 | 81.5 | 76.9 | 30.8 |
| % time < 70 mg/dL | 1.2 | 0.0 | 0.0 | 12.8 | 15.4 | 23.1 |
| % time < 54 mg/dL | 0.0 | 0.0 | 0.0 | 0.8 | 0.0 | 0.0 |
Abbreviations: r-MPC, regular model predictive control; MS-MPC, multistage model predictive control.
# hypo treats during exercise indicates the number of hypo treatments (15 g CHO, fast absorption) given to the entire in silico cohort during the exercise period.