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. 2019 Sep 26;11(11):e10697. doi: 10.15252/emmm.201910697

Figure 1. Scalp psoriasis exhibits reduced expression of c‐JUN and JUNB in hair follicle stem cells (HF‐SCs).

Figure 1

  • A–D
    Representative composite immunofluorescence images of whole hair follicle units from non‐lesional and lesional scalp psoriasis patients. K15 (green), c‐JUN (red in A, C) and JUNB (red in B, D) and DAPI (blue).
  • E–H
    Confocal images of the bulge region of human psoriatic hair follicles from non‐lesional and lesional regions of the scalp. K15 (green), c‐JUN (red in E, G) and JUNB (red in F, H) and DAPI (blue).
  • I, J
    Percentage of HF‐SCs (K15+) that express c‐JUN (I) and JUNB (J) in the bulge region of human psoriatic hair follicles from non‐lesional and lesional scalp in comparison with healthy scalp. n = 2–6 hair follicles in anagen per group from five psoriatic patients and two healthy patients. Data represent mean ± SD. Statistical significance *P < 0.05, **P < 0.01, ***P < 0.001 (Student's two‐tailed t‐test relative to controls). See Appendix Table S2 for exact P‐values.

Source data are available online for this figure.