. 2019 Oct 6;11(10):2382. doi: 10.3390/nu11102382

Table 4.

Final changes in total plasma B12 and the combined metabolic index following administration of CN-B12 and HO-B12.

Dose and Time	Total Plasma ΔB12 ², pmol/L, mean ± SE		ΔcB12_metabolic ² mean ± SE
	CN-B12	HO-B12	CN-B12	HO-B12
2 × 0.76 µg/day ¹ four weeks [8]	+30 ± 7	+29 ± 15	+0.37 ± 0.08	+0.29 ± 0.11
2 × 0.76 µg/day ¹ four weeks [8]	p = 0.95		p = 0.55
3 µg/day eight weeks [25]	+55 ± 6	+37 ± 8	+0.33 ± 0.61	+0.22 ± 0.11
3 µg/day eight weeks [25]	p = 0.07		p = 0.86
2 × 2.8 µg/day eight weeks (present study)	+97 ± 20	+47 ± 13	+0.70 ± 0.13	+0.59 ± 0.08
2 × 2.8 µg/day eight weeks (present study)	p = 0.04		p = 0.48

¹ The data for HO-B12 were taken according to cow milk supplementation. ² The final levels of ΔB12 and ΔcB12_metabolic were evaluated according to exponential approximations (Equation (1)), though the precise shapes of dependencies can be argued. Probability p of equal end-values for CN-B12 vs. HO-B12 data was assessed by t-test.