Table 2.

Advantages and disadvantages of oral dispersible dosage forms.

Advantages	Disadvantages
Dosing
Once dispersed in liquid is easy to swallow; suitable for the whole pediatric population from birth upwards	Limited dose flexibility, although a break line may be introduced to sub-divide tablets; granules generally provided in unit-dose packs (e.g., sachet); more than one dose strength may be needed to cover the required dose range
Administration
Generally non-complex and simple method of administration, with no need for measuring device (e.g., dosing cup, spoon, or oral syringe)	Requires dispersion in water or other beverage prior to administration; whole volume of liquid dispersion must be taken; rinsing of vessel may be required to ensure all residue (if any) is taken
Excipient Safety
Do not require the inclusion of preservatives; many excipients commonly used in dispersible dosage forms have an acceptable safety profile in pediatric patients	May require sweetener and/or flavor to ensure acceptable palatability
Stability
Better stability than liquids or semi-solids	May need moisture protective packaging; in-use stability once dispersed likely to be limited; compatibility with dispersing vehicle should be confirmed
Manufacture and Supply Chain
Non-complex development process; standard manufacturing and packaging equipment may be used; low bulk/footprint; easy to store and transport	Humidity control may be required during manufacture