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Long-term chemical stability upon storage at 4 °C of: CEF in 20% w/v PF127 hydrogel (dashed grey), dCEF-M-TNH (dashed black), dCEF-SLN (grey), dCEF-S-TNH (black). Each bar represents the mean ± SD (n = 5). Significant differences versus CEF reference started from the 15th days for the dCEF-preparations (p < 0.05), among the dCEF preparations no significative differences were noted during 28 days (p > 0.05).
