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. 2019 Oct 15;11(10):2473. doi: 10.3390/nu11102473

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Plasma concentration–time profiles of the five drugs (IV doing) after administration of a single oral dose of adlay bran oil (ABO) in rats. Drug cocktail (CYP1A2: theophylline (a), CYP2C: diclofenac (b), CYP2D: dextromethorphan (c), CYP2E1: chlorzoxazone (d), CYP3A: diltiazem (e) was administered intravenously at a dose of 1–10 mg/kg body weight (BW) to rats 1 h after administration of control oil (soybean oil; 2.5 mL/kg BW) or ABO (2.5 mL/kg BW). Values at each time point are expressed as the mean ± SD of six rats in each group. ●: Control group; ○: ABO group.

Plasma concentration–time profiles of the five drugs (IV doing) after administration of a single oral dose of adlay bran oil (ABO) in rats. Drug cocktail (CYP1A2: theophylline (a), CYP2C: diclofenac (b), CYP2D: dextromethorphan (c), CYP2E1: chlorzoxazone (d), CYP3A: diltiazem (e) was administered intravenously at a dose of 1–10 mg/kg body weight (BW) to rats 1 h after administration of control oil (soybean oil; 2.5 mL/kg BW) or ABO (2.5 mL/kg BW). Values at each time point are expressed as the mean ± SD of six rats in each group. ●: Control group; ○: ABO group.