Figure 4.
Plasma concentration–time profiles of five drugs (PO dosing) after the oral administration of soybean oil or the ABO-containing diet for 7 days in rats. The drug cocktail (CYP1A2: theophylline (a), CYP2C: diclofenac (b), CYP2D: dextromethorphan (c), CYP2E1: chlorzoxazone (d), CYP3A: diltiazem (e) was administered orally at a dose of 5–40 mg/kg BW to rats. Values at each time point are expressed as the mean ± SD of six rats in each group. ●: Control group; ○: ABO group.