Table 1.
Pharmacokinetic parameters of five drugs (IV dosing) after the administration of a single oral dose of ABO in rats 1.
| Drugs | Dose (mg/kg) | AUC (0-t) 2 (μg/mL×h) | T 1/2 (h) | Cl 3 (mL/min/kg) |
|---|---|---|---|---|
| Theophylline (CYP1A2) | ||||
| Control group | 1 | 4.6 ± 0.8 | 3.2 ± 1.1 | 12.7 ± 2.3 |
| ABO group | 4.5 ± 0.7 | 3.7 ± 0.6 | 12.5 ± 1.7 | |
| Diclofenac (CYP2C) | ||||
| Control group | 10 | 30.1 ± 3.2 | 2.9 ± 2.1 | 19.2 ± 2.3 |
| ABO group | 28.7 ± 6.7 | 2.6 ± 2.1 | 20.5 ± 5.3 | |
| Dextromethorphan (CYP2D) | ||||
| Control group | 5 | 0.76 ± 0.17 | 2.4 ± 0.7 | 388.4 ± 65.8 |
| ABO group | 0.89 ± 0.08 | 4.2 ± 3.7 | 318.4 ± 27.9 | |
| Chlorzoxazone (CYP2E1) | ||||
| Control group | 1 | 3.0 ± 0.6 | 1.7 ± 0.6 | 20.1 ± 4.3 |
| ABO group | 3.0 ± 0.7 | 2.4 ± 1.0 | 18.1 ± 2.9 | |
| Diltiazem (CYP3A) | ||||
| Control group | 5 | 5.1 ± 0.7 | 2.2 ± 1.4 | 128.9 ± 16.6 |
| ABO group | 4.3 ± 1.2 | 1.9 ± 0.3 | 115.3 ± 13.9 |
1 Drug cocktail was administered intravenously at a dose of 1–10 mg/kg BW to rats 1 h after the administration of control oil or ABO. Pharmacokinetic parameters were expressed as the mean ± SD of six rats in each group. 2 AUC: area under the plasma drug concentration curve. t = 12 h. 3 Cl: Clearance, the volume of plasma from which a drug is removed per unit time.