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. 2019 Oct 13;11(10):2439. doi: 10.3390/nu11102439

Figure 2.

Figure 2

High NR induces lower glucose tolerance and higher circulating insulin levels during an oral glucose tolerance test (OGTT). Blood glucose was measured at indicated timepoints before and after an oral glucose administration (a) and iAUC was calculated to assess glucose tolerance (b). Plasma insulin was measured at indicated timepoints during OGTT (c) and iAUC (Baseline = 1.994) was analyzed (d). Plasma insulin at t = 0 represents fasted circulating insulin (e) and the corresponding HOMA-IR was calculated to assess insulin resistance (f). Control NR: open square with solid line or white bar; high NR: closed diamond with black dashed line or black bar. NR in mg/kg diet. Data are analyzed using either two-way repeated measures ANOVA followed by Bonferroni post-hoc analysis (a,c) or Student’s t-test (b,d–f), and presented as mean ± SEM (n = 11–12 mice per treatment). * p < 0.05, ** p < 0.01, **** p < 0.001.