Table 2.
Effect of Vitamin D supplementation on risk of relapse or death and death in subgroups stratified by histopathological characteristics.
| Risk of Relapse or Death | Risk of Death | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subgroups | N | Events | HR | 95%CI | p-Value | Events | HR | 95%CI | p-Value |
| Well | |||||||||
| Vitamin D | 139 | 28 | 0.81 | 0.46–1.44 | 0.48 | 19 | 0.82 | 0.40–1.65 | 0.57 |
| Placebo | 79 | 20 | 1.00 | 13 | 1.00 | ||||
| Moderately | |||||||||
| Vitamin D | 97 | 22 | 1.06 | 0.56–2.02 | 0.86 | 15 | 1.31 | 0.57–2.99 | 0.53 |
| Placebo | 69 | 16 | 1.00 | 9 | |||||
| Poorly | |||||||||
| Vitamin D | 45 | 4 | 0.25 | 0.08–0.78 | 0.017 | 3 | 0.25 | 0.07–0.94 | 0.040 |
| Placebo | 36 | 11 | 1.00 | 8 | 1.00 | ||||
| Signet-ring | |||||||||
| Vitamin D | 20 | 1 | 0.19 | 0.02–1.57 | 0.12 | 1 | 0.30 | 0.03–2.65 | 0.28 |
| Placebo | 24 | 6 | 1.00 | 4 | 1.00 | ||||
| SCC | |||||||||
| Vitamin D | 19 | 8 | 0.94 | 0.33–2.73 | 0.91 | 7 | 1.39 | 0.35–5.49 | 0.64 |
| Placebo | 13 | 6 | 1.00 | 3 | 1.00 | ||||
P value was determined using a Cox proportional hazards model. CI, confidential interval; HR, hazard ratio; Well, well differentiated type of tubular adenocarcinoma; Moderately, moderately differentiated type of tubular adenocarcinoma; Poorly, poorly differentiated adenocarcinoma; Signet-ring, signet-ring cell carcinoma; SCC, squamous cell carcinoma.