Figure 3.

Tissue accumulation of vitC depends on both local and systemic conditions. The ratios are based on data obtained from guinea pigs that like human cannot synthesize vitC [7]. (a): During sufficiency, tissues accumulate vitC primarily through the sodium-dependent vitC transporters (SVCTs) perhaps with a small contribution from influx of DHA, which is rapidly converted to ASC. (b): During deficiency, prioritized retainment of vitC occurs in, for example the brain, at the expense of other tissues (c): where increased oxidative stress may result in elevated DHA concentrations, limited recycling capacity and poor tissue accumulation through DHA influx.