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Blocking immune pathways resulted in a high level of viral gene expression. (A) The gene expression of the sigma virus in JAK-STAT pathway knockdown in S2 cells. The expression of all genes increased, and that of the L gene showed the highest increase (i.e., 4-fold). (B) Gene expression of sigma virus in the IMD pathway-knockdown cells. The mean and SD are shown. ** p < 0.005; * p < 0.05 one-sample t-test. All experiments were performed with three biological replicates.
