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. 2019 Oct 3;11(10):1609. doi: 10.3390/polym11101609

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Wound healing model in mouse. (a) The gross observations revealed that all surgical created wound beds closed as time. However, the use of a PLGA nanofibrous mesh did not improve wound closure when compared to that of untreated wounds (control). On the contrary, the cECM/PLGA mesh enhanced wound healing, and the wound was almost closed at day 14. (b) The decrease in wound area indicated that mice received the cECM/PLGA meshes had a significant smaller wound size while there was no obvious difference between PLGA nanofiber and control group.