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. 2019 Oct 4;11(10):512. doi: 10.3390/pharmaceutics11100512

Table 2.

Modulation of PTX cytotoxicity in drug-sensitive Hep3B and drug-resistant Hep3B/PTX cell lines by Achillin.

Treatment PTX
aIC50 nM (RRI) b
Hep3B Cells		 PTX
aIC50 nM (RRI) b
PTX/Hep3B Cells
PTX alone 25 ± 5 352 ± 12 a
PTX + Achillin 100 µM 19.5 ± 3 (1.28) 38 ± 5 (9.1)
PTX + Verapamil 20 µM 21.4 ± 4.2 (1.16) 33 ± 10 (10)

a Required amount of drug alone to reduce the growth of the cell lines by 50%. b Resistance Reversion Index (RRI) = (IC50 of drug alone)/(IC50 of drug in combination with modulator).