Table 3.

Cytotoxicity of PTX against Hep3B/PTX cells, either alone or combinations with Achillin. The IC₅₀ (µM) are presented as the mean ± SD. CI values <1 signify synergism; =1: additive effects; >1: antagonism. 0.3 < CI < 0.7 means synergism (+++), 0.7–0.85 moderate synergism (++). NR = not relevant. DRI = dose reduction indexes.

Treatment	IC50 PTX	DRI	CI	Interpretation
PTX alone	0.352 ± 0.012	1	NR	NR
PTX + Achillin	-	-	-	-
100 µM (IC20)	0.038 ± 0.0091	9.2	0.5	+++
160 µM (IC40)	0.03 ± 0.007	7.3	0.88	++