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. 2019 Sep 29;11(10):2310. doi: 10.3390/nu11102310

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Global metabolomic analysis of plasma metabolites. Blood samples were collected at ZT5 (day) and at ZT17 (night) from 10-month-old db/db (diabetic) and aged-matched db/m (control) mice. Untargeted global metabolomics analysis was performed with the Metabolon Platform (Metabolon Inc). Statistically significant different metabolites were used for the analysis with MetaboAnalyst. (A) PCA analysis. (B) Metabolic pathway analysis of metabolites that were different in the transition from day to night in control and diabetic groups. (C) Venn graphs of metabolites that were different in the transition from day to night in control and diabetic groups. (D) Enrichment analysis of metabolites that similarly changed in the transition from day to night in control and diabetic groups. (E) Enrichment analysis of metabolites that changed in the transition from day to night only in control. (F) Enrichment analysis of metabolites that changed in the transition from day to night only in diabetes. n = 3 per time point per group.