Table 2.
Effect of fucoidan on cytokine production.
| Group | Dose (mg/kg) | Con A (5.0 μg/ mL) | LPS (10.0 μg/ mL) |
|---|---|---|---|
| IL-2 (pg/mL) | |||
| NC | - | 2625.1 ± 526.1 a | 34.1 ± 5.6 a |
| FL | 102.5 | 2944.2 ± 874.0 a,b | 38.9 ± 6.8 a,b |
| FM | 205.0 | 3184.5 ± 519.1 a,b | 39.3 ± 3.5 a,b |
| FMH | 410.0 | 3223.4 ± 539.6 b | 39.9 ± 5.6 a,b |
| FH | 1025.0 | 3249.2 ± 452.4 b | 41.9 ± 10.1 b |
| IL-4 (pg/mL) | |||
| NC | - | 51.9 ± 11.2 a | 14.3 ± 2.8 a |
| FL | 102.5 | 43.9 ± 13.2 a | 10.6 ± 0.9 b |
| FM | 205.0 | 41.4 ± 15.0 a,b | 10.7 ± 1.7 b |
| FMH | 410.0 | 42.1 ± 14.7 a,b | 10.2 ± 1.2 b |
| FH | 1025.0 | 31.2 ± 8.8 b | 9.7 ± 0.8 b |
| IL-5 (pg/mL) | |||
| NC | - | 121.9 ± 41.3 a | 10.0 ± 1.8 a |
| FL | 102.5 | 78.9 ± 14.5 b | 7.6 ± 1.0 b |
| FM | 205.0 | 71.6 ± 17.6 b | 7.4 ± 1.0 b |
| FMH | 410.0 | 68.4 ± 15.7 b | 7.1 ± 0.7 b |
| FH | 1025.0 | 65.8 ± 19.2 b | 7.0 ± 0.8 b |
| IFN-γ (ng/mL) | |||
| NC | - | 19.3 ± 4.8 a | 4.0 ± 0.9 a |
| FL | 102.5 | 20.4 ± 5.3 a | 5.1 ± 1.3 a,b |
| FM | 205.0 | 24.3 ± 6.8 a | 5.9 ± 2.4 b |
| FMH | 410.0 | 24.4 ± 7.7 a | 6.6 ± 1.9 b |
| FH | 1025.0 | 24.5 ± 5.2 a | 8.8 ± 2.8 c |
All data are presented as mean ± SD (n = 10 mice/group). All experiments were performed once per test condition. Different letters indicate significant differences (p < 0.05).