Table 1.
Drug–dietary supplement interactions and their consequences.
| Prescription Medicine | Dietary Supplement | Potential Clinical Consequences of the Interaction | Prevalence of Potential Interactions |
|---|---|---|---|
| Tetracyclines | Calcium | Decreased therapeutic effect as a consequence of a reduction in the absorption of tetracycline [3]. | 44.3% |
| Magnesium | Decreased therapeutic effect as a consequence of a reduction in the absorption of tetracycline [3,5]. | 26.9% | |
| Zinc | Decreased therapeutic effect as a consequence of a reduction in the absorption of tetracycline [3,5]. | 37.4% | |
| Thiazides | Calcium | Hypercalcemia and metabolic alkalosis. Thiazides reduce the urinary excretion of calcium. Vitamin D increases the absorption of calcium [5]. | 53.5% |
| Vitamin D | 52.1% | ||
| Angiotensin II receptor blockers | Potassium | Higher risk of hyperkalaemia, especially in patients with decreased renal function, heart failure, or diabetes [5]. | 28.8% |