Table 7.

MicroRNA (miRNA) regulating natural compounds.

Compound	Classification	Source	Organism	Cell Line/Animal Model	Dose; Duration	Mechanism	Reference
Luteolin, Ellagic acid, Punicic acid	Flavones, polyphenols	Pomegranate juice	Plant	PC3	8 µg/mL/12 h	miR144, miR-133b, miR-1, miR-122, miR-34c, miR-200c, miR-127, miR-335, miR-124, miR-181a, miR-7, miR-215, miR-15a, Let-7d, miR-20a, miR-21, miR-9, miR-29b, miR-181b↓	[79]
Epigallocatechin-3-gallate	Polyphenols, Flavan	Green tea	Plant	PCa xenografts	3 mg/6 weeks	miRNA-330↑ miRNA-21↓	[80]
Green tea polysaccharide	Polysaccharide	Camellia sinensis L.	Plant	PC3	25, 50, 100 μg/mL/48 h	miR-93↓	[81]
Resveratrol	Stilbenoid	N/A	Plant	DU145, LNCaP	50 mM/24 h	miR-17, miR-20a, miR-20b, miR-106a, miR-106b↑	[82]
Genistein	Isoflavone	N/A	Plant	PC3, DU145	25μM/4 days	sFRP1, Smad4↑ miR-1260b↓	[83]
Curcumin	Polyphenol	Curcoma longa	Plant	TRAMP C1	2.5 μM; 5 days	Nrf 2, NQO-1↑	[84]
EF24	Polyphenol	Curcoma longa	Plant	DU145	5 µM; 24 h	miR-345, miR-409, miR-10a miR-206↑ miR-21, miR-26a, miR-24, miR-30b miR-29a↓	[85]
Genistein, Daidzein	Isoflavones	Soy	Plant	PC-3, DU-145, LNCaP	40 μM, 110 μM; 48 h	GSTP1, EPHB2↑	[86]
Gefitinib, Luteolin	Anilinoquinazoline, Flavones	Reseda luteola	Plant	PC-3, U2OS	60 μM, 60 μM; 24 h, 48 h, 72 h	miR-630, miR-5703↑	[87]

N/A, not available; ↑, up-regulated; ↓, down-regulated.