Table 3.
Type of Biomimetic Nanoparticle (NP) | Therapeutic Cargo | Application | Reference |
---|---|---|---|
Liposome | Hepa 1-6 cell lysate and Poly I:C | High tumor specific CTL immune response | [145] |
P5 peptide and Poly I:C | CTL immune response and anti-cancer therapy | [130] | |
Tumor associated ESO-1 antigen and IL-1, MAP-IFN-γ | Fcγ receptor targeting and anti-cancer therapy | [146] | |
OVA antigen | CTL response and cancer immune therapy | [147] | |
Endolysin | Degradation of bacterial protein and anti-bacterial therapy | [102] | |
Env-2-3-SF2, IL-7 | Strong antibody response and anti-HIV therapy | [107] | |
MPER and MPLA, STING, cdGMP | Strong T-cell response and anti-HIV therapy | [108] | |
MSP-1 | Activation of epidermal APC | [121] | |
Virus like NP | CFP 10 | CTL activity, Th1 immune response, and anti-bacterial therapy | [101] |
HIV env antigen | Maintaining the germinal center, and releasing neutralizing antibody for anti-HIV therapy | [110] | |
CSP-hepatitis B surface antigen and Abisco-100, Matrix-M | Targeting infected erythrocytes and CD8 + T-cell responses in anti-malaria therapy | [123] | |
HER-2 antigen | Th1 & Th2 type antibody response and anti-cancer therapy | [139] | |
Outer membrane coated nanovaccine | Alum adjuvant | Th2 type immune response anti-bacterial therapy | [148] |
RBC membrane coated Nanovaccine | None | Adsorption of bacterial endotoxin | [149] |
None | Natural substrate for PFT for Anti-melittin therapy | [142] | |
T-cell coated Nanovaccine | None | Inhibition of viral attack to host cell | [113] |
Cancer cell membrane coated Nanovaccine | PD-L 1 siRNA | Tumor targeting and anti-cancer therapy | [132] |
CpG oligodeoxynucleotide | Stimulation of APC maturation and release of pro-inflammatory cytokines in anti-cancer therapy | [134] |
(Poly I:C -Polyinosinic:polycytidylic acid, ESO 1- esophageal cancer, MAP-IFN-γ - multiple antigenic peptide- interferon -γ, Env- envelope glycoprotein, MPER- membrane-proximal external region, MPLA- monophosphoryl lipid A, STING- stimulator of interferon gene, cdGMP- cyclic-di-GMPHER-2: human epidermal growth factor receptor 2, OVA: ovalbumin and MSP: merozoite surface protein, CFP-10- culture filtrate protein 10).