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Unsupervised PCA plots comparing normalization approaches for RPLC data showing (A) raw data, (B) SVR-normalized data, (C) SVR and creatinine-normalized data, (D) SVR and specific gravity-normalized data, and (E) SVR and PQN-normalized data. Abbreviations: RPLC, reversed-phase liquid chromatography; SVR, support vector regression; PQN, probabilistic quotient normalization; PC1, principal component 1; PC2, principal component 2; ellipse is a 95% confidence ellipse.
