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. 2019 Oct 5;11(10):515. doi: 10.3390/pharmaceutics11100515

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evaluation of the pharmacodynamic effects of EF-2 via assessing its suppressive effect on c-MET activation, the main OC validated molecular target in BT-474 cells in nude mouse xenograft models. Left panel: Western blot analysis of excised primary tumors. Right panel: western blot analysis of recurrence tumors. Bottom panels: Scanning densitometric analysis and the integrated optical density of each band was normalized with corresponding β-tubulin. Error bars indicate ± SEM for n = 5. *p < 0.05 as compared to vehicle-treated controls.