Figure 6.

Biplot (scores of samples and load factors of each variable) of the principal component analysis (PCA) (A), including the content of free amino groups (NH₂), fructosamine (FRUCT), fluorescent AGE (FL-AGE), total AGE (T-AGE), and protein carbonyls (CARB) (A), and a dendrogram of the hierarchical cluster analysis of the glycation inhibitory activity (B) of the samples of the BSA-MGO glycation system (72 h incubation, 37 °C, pH 7.4) BSA: negative control; MGO: BSA + methylglyoxal; AMG: BSA + methylglyoxal + aminoguanidine; CSE: BSA + methylglyoxal + CSE (12,5 mg mL⁻¹); CGA1: BSA + methylglyoxal + 1 mmol L⁻¹ CGA; CGA5: BSA + methylglyoxal + 5 mmol L⁻¹ CGA; CGA10: BSA + methylglyoxal + 10 mmol L⁻¹ CGA; GEN: BSA + methylglyoxal + 5 mmol L⁻¹ genistein; MEL: BSA + methylglyoxal + 5 mmol L⁻¹ melatonin.