Table 1.
Effects of docosahexaenoic acid (DHA) administration on hepatic fatty acid composition in healthy and cirrhotic rats.
| Fatty Acid | Healthy Vehicle | Healthy DHA | Cirrhotic Vehicle | Cirrhotic DHA |
|---|---|---|---|---|
| SFA | ||||
| MA (14:0) | 0.39 ± 0.04 | 0.31 ± 0.03 | 0.43 ± 0.01 | 0.30 ± 0.02 ** |
| PA (C16:0) | 21.09 ± 0.31 | 21.48 ± 0.67 | 23.28 ± 0.41 ### | 24.58 ± 0.39 |
| SA (C18:0) | 17.82 ± 0.26 | 17.40 ± 0.72 | 14.43 ± 0.88### | 16.02 ± 0.54 |
| MUFA | ||||
| POA (C16:1 n-7) | 1.74 ± 0.17 | 1.68 ± 0.22 | 2.64 ± 0.30 | 1.74 ± 2.13 * |
| OA (C18:1 n-9) | 8.40 ± 0.54 | 7.33 ± 0.40 | 15.70 ± 1.32 ### | 8.87 ± 0.22 *** |
| VAC (C18:1 n-7) | 3.77 ± 0.29 | 3.03 ± 0.10 | 3.36 ± 0.16 | 2.85 ± 0.16 |
| EIA (C20:1 n-9) | 0.13 ± 0.01 | 0.11 ± 0.01 | 0.12 ± 0.01 | 0.12 ± 0.01 |
| NA (C24:1 n-9) | 0.27 ± 0.02 | 0.24 ± 0.01 | 0.29 ± 0.03 | 0.34 ± 0.03 |
| PUFA | ||||
| n -3 series | ||||
| ALA (C18:3 n-3) | 0.40 ± 0.04 | 0.43 ± 0.05 | 0.40 ± 0.03 | 0.25 ± 0.02 *** |
| ETE (C20:3 n-3) | 0.30 ± 0,02 | 0.22 ± 0.02 * | 0.28 ± 0.02 | 0.13 ± 0.02 ** |
| EPA (C20:5 n-3) | 0.18 ± 0.03 | 1.4 ± 0.26 ** | 0.11 ± 0.02 | 1.25 ± 0.08 *** |
| DPA (C22:5 n-3) | 0.59 ± 0.03 | 1.41 ± 0.16 ** | 0.64 ± 0.03 | 1.42 ± 0.08 *** |
| DHA (C22:6 n-3) | 5.85 ± 0.48 | 9.82 ± 0.52 ** | 1.97 ± 0.25 ### | 11.70 ± 0.45 *** |
| n -6 series | ||||
| LA (C18:2 n-6) | 17.63 ± 0.54 | 18.37 ± 0.31 | 18.13 ± 0.42 | 17.32 ± 0.29 |
| GLA (C18:3 n-6) | 0.16 ± 0.01 | 0.11 ± 0.01 * | 0.32 ± 0.02 | 0.08 ± 0.01 *** |
| HGLA (C20:3 n-6) | 0.52 ± 0.05 | 0.84 ± 0.05 *** | 0.,32 ± 0.02 | 0.82 ± 0.05 *** |
| AA (C20:4 n-6) | 18.59 ± 0.32 | 14.76 ± 0.72 *** | 14.86 ± 0.90 ### | 10.25 ± 0.34 *** |
| DTA (C22:4 n-6) | 0.49 ± 0.02 | 0.20 ± 0.02 *** | 0.73 ± 0.07 | 0.21 ± 0.01 *** |
| DPA (C22:5 n-6) | 0.26 ± 0.01 | 0.20 ± 0.02 | 1.07 ± 0.18 | 0.24 ± 0.02 *** |
| Total SFA | 40.26 ± 0.54 | 40.11 ± 0.90 | 39.01 ± 0.53 | 42.07 ± 0.35 *** |
| Total MUFA | 14.31 ± 0.93 | 12.34 ± 0.56 | 22.11 ± 1.55 ### | 13.93 ± 0.36 *** |
| Total PUFA | 45.44 ± 0.97 | 47.50 ± 0.74 | 38.88 ± 1.08 ### | 43.99 ± 0.37 *** |
| Total n-3 FA | 7.32 ± 0.54 | 12.94 ± 0.86 *** | 3.11 ± 0.24 ### | 14.74 ± 0.47 *** |
| Total n-6 FA | 38.11 ± 0.76 | 34.55 ± 0.65 *** | 35.77 ± 0.85 | 29.26 ± 0.33 *** |
Results represent percentage (%) of total fatty acids and are expressed as mean ± S.E.M. n = 5 for healthy animals and n = 11 for cirrhotic animals. # <0.05; ## <0.01; ### <0.001 vs. healthy vehicle group and * <0.05; ** <0.01; *** <0.001 vs. corresponding group receiving vehicle. AA, arachidonic acid; ALA, alpha linolenic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; DTA, docosatetraenoic acid; EIA, eicosenoic acid; EPA, eicosapentaenoic acid; ERA, erucic acid; ETE, eicosatrienoic acid; FA, fatty acid; GLA, gamma linoleic acid; HGLA, homogamma linolenic acid; LA, linoleic acid; MA, myristic acid; MUFA, monounsaturated fatty acid; NA, nervonic acid; OA, oleic acid; PA, palmitic acid; POA, palmitoleic acid; PUFA, polyunsaturated fatty acid; SA, stearic acid; SFA, saturated fatty acid; VAC, vaccenic acid.