Table 4.
Concentration of thiol and thioether metabolites in healthy individuals (n = 11).
| Metabolite (µmol/L) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject ID | Cys-Free | GSH-Free | Hcy-Free | Cysta | Cys | CSSC | GSH | GSSG | Hcy | HSSH | Met | MSO |
| Subject 1 | 7.4 | 3.6 | 0.11 | 0.42 | 248 | 54 | 6.4 | 0.3 | 6.9 | 0.045 | 32 | 1.0 |
| Subject 2 | 6.1 | 3.7 | 0.14 | 0.14 | 264 | 54 | 10.1 | 1.8 | 8.1 | 0.019 | 30 | 0.7 |
| Subject 3 | 6.0 | 2.6 | 0.10 | 0.18 | 312 | 59 | 7.5 | 4.0 | 12.8 | 0.029 | 28 | 0.9 |
| Subject 4 | 5.9 | 2.4 | 0.17 | 0.15 | 275 | 49 | 8.6 | 3.9 | 13.5 | 0.030 | 32 | 1.2 |
| Subject 5 | 5.9 | 2.2 | 0.11 | 0.17 | 237 | 48 | 7.0 | 4.1 | 9.4 | 0.021 | 40 | 1.0 |
| Subject 6 | 7.4 | 1.6 | 0.15 | 0.15 | 234 | 55 | 7.4 | 3.9 | 6.1 | 0.021 | 48 | 1.8 |
| Subject 7 | 6.8 | 1.7 | 0.21 | 0.14 | 217 | 46 | 6.4 | 3.6 | 7.9 | 0.024 | 34 | 1.7 |
| Subject 8 | 7.9 | 1.5 | 0.22 | 0.32 | 285 | 63 | 7.1 | 4.3 | 10.8 | 0.065 | 44 | 1.9 |
| Subject 9 | 5.5 | 1.7 | 0.09 | 0.19 | 246 | 52 | 7.4 | 4.1 | 6.9 | 0.020 | 34 | 1.4 |
| Subject 10 | 4.0 | 3.6 | 0.17 | 0.16 | 257 | 53 | 6.8 | 4.1 | 8.4 | 0.019 | 26 | 0.8 |
| Subject 11 | 4.8 | 1.9 | 0.14 | 0.31 | 307 | 68 | 6.7 | 3.9 | 10.7 | 0.031 | 33 | 1.2 |
| Mean | 6.2 | 2.4 | 0.15 | 0.21 | 262 | 54 | 7.4 | 3.5 | 9.2 | 0.029 | 35 | 1.2 |
| SD | 1.2 | 0.9 | 0.04 | 0.09 | 30 | 7 | 1.1 | 1.2 | 2.4 | 0.014 | 7 | 0.4 |
| Reference range (a) | 8.3–10.7 | 2.0–5.1 | 0.17–0.32 | <0.4 | 202–281 | 41–63 | 4.9–7.3 | 0.7–1.6 | 6.5–11.9 | 1.0–1.2 | 18–35 | N/A (b) |
(a) Reference ranges were taken from Turell et al. (Free Radic. Biol. Med. 2013, 65, 244–253) and from Bevital Laboratories (Bevital AS, Bergen, Norway); (b) In a study of 8 healthy human subjects, a reference value of 4.0 ± 1.0 µM was established (Analytical Biochemistry, Volume 313, Issue 1, 1 February 2003, Pages 28–33). The authors stated that MSO amounts to approximately 10% of the concentration of Met.