Table 3.
Predicted/novel antioxidant sequences obtained by integrated computational methods and rational design.
| Sequence 1 | Methodology | Evaluation | Ref. |
|---|---|---|---|
| PHH | LLPHH-related peptides | Activity against peroxidation of linoleic acid | [82] |
| YHY, XXW, | Tripeptide library, | Activity against peroxidation of linoleic acid, | [84,85] |
| XXY, XXC | QSAR modeling | reducing activity, radical and peroxynitrite | |
| scavenging activity, Trolox equivalent | |||
| antioxidant capacity (TEAC), ferric | |||
| reducing antioxidant activity | |||
| ECH, YECG | Rational design | Radical scavenging activity, reducing power, | [86] |
| activity against peroxidation of linoleic acid, | |||
| oxygen radical absorbance capacity (ORAC), | |||
| TEAC, protection on H2O2-induced cytotoxicity | |||
| YX, XY, | Library of Y-, W-, C- | Radical scavenging activities, reducing power, | [87] |
| WX, XW | or M-containing dipeptides, | iron chelating activity, protective effect on | |
| QSAR modeling | erythrocyte hemolysis | ||
| YGY, YGGY, | Rational design | Antioxidant activities against hypochlorite ion, | [88] |
| GYYG, GWWW | hydroxyl radical, peroxynitrite | ||
| QP, PY | Rational design | Radical scavenging activity, iron chelating | [18] |
| activity, ORAC, cell response studies | |||
| ECRMR | Rational design, | Radical scavenging activity | [89] |
| 3D-QSAR modeling |
1 In bold those that are found within the primary sequence of food proteins.