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Treatment with peroxisome proliferator activated receptor α (PPARα) agonist, Wy14,643, induces ketogenic gene expression in Glut1+/− mice. Hepatic expression of genes relevant for fatty acid β-oxidation (Acadl, Acadm, Acox1, Hadh, Acsl1, Slc25a20) and ketogenesis (Hmgcs2) in vehicle (grey bars) and Wy14,643-treated (blue bars) Glut1+/− mice; ** p < 0.01; *** p < 0.001; **** p < 0.0001.
