Table 1.
Characterization of copolymers and their DOX-loaded micelles.
| Sample | Mn,tha (kDa) | Weight Ratio of Hydrophobic Dendron b (%) | Mn,NMR (kDa) (DP) c | Mn,GPCd (kDa) | Ð d (Mw/Mn) | DL e (w/w, %) | EE e (w %) |
|---|---|---|---|---|---|---|---|
| PNVP | 9.8 | - | 10.0 (88) | 29.0 | 1.28 | - | - |
| PNVP-b-dendr(Phe-Lys) | 10.6 | 8 | - | 33.8 | 1.34 | - | - |
| PNVP-b-dendr(Phe-Lys)2 | 11.6 | 16 | - | 35.4 | 1.32 | 2.7 | 71.2 |
| PNVP-b-dendr(Phe-Lys)3 | 13.6 | 28 | - | 37.6 | 1.32 | 3.0 | 71.6 |
a The theoretic molecular weight was calculated by the formula: Mn,th = Mmonomer × ((monomer)/(CTA-Boc)) × Conversion% + MCTA-Boc. b Weight ratios based on theoretical values. c The degree of polymerization of the copolymers was calculated using Mn,NMR. d Mn,GPC and PDI were determined by GPC in relative to PMMA standards. e Drug loading (DL) and encapsulation efficiency (EE) of DOX-loaded micelles was calculated by the formulae in Experimental Section.