Figure 5.

The open field test indicated that the oral administration of DIPH, but not PS150^TM, affected locomotor activity in mice: (a) center square time, (b) total distance. The experimental design is shown in Figure 4a; a 10-min open field test was performed after the injection of PBS or caffeine (15 mg/kg). PS150^TM was orally administrated for 28 consecutive days. DIPH (20 mg/kg), as a drug control group, was introduced on experimental day 28. Data are expressed as mean ± SEM (n = 8~10) and were analyzed by one-way ANOVA with Tukey’s post hoc test. * p < 0.05, compared with the indicated groups.