Table 3.
Costs by cost category, mean costs and cost differences discounted, adjusted and unadjusted, given in € (2015)
| mean costs (SD) per patient | |||||||
|---|---|---|---|---|---|---|---|
| category | standard (IMRT only) [€] | SD (IMRT only) | experimental (IMRT + C12) [€] | SD (IMRT + C12) | mean cost difference [€] | 95% CI, non-parametric bootstrapping (€) | p-value |
| initial treatment | 5.68 | – | 17.88 | – | 11.2 | – | |
| diagnostic follow-up | 2.66 | 1.47 | 3 | 1.11 | 332 | − 219; 955 | 0.165 |
| treatment of recurrence | |||||||
| surgery | 2.03 | 6.37 | 4.82 | 8.35 | 2.78 | 8; 6.039 | 0.002 |
| re-RT | 2.18 | 4.92 | 4.93 | 11.98 | 2.75 | − 813; 6.376 | 0.179 |
| chemotherapy | 3.03 | 3.42 | 2.46 | 3.3 | − 572 | − 2023; 834 | 0.378 |
| palliative RT | 105 | 287 | 103 | 267 | −3 | − 131; 105 | 0.688 |
| total complication costs | 7.35 | 8.51 | 12.31 | 16.99 | 4.95 | 192; 10,501 | 0.019 |
| mean total costs (unadjusted) | |||||||
| undiscounted | 15.76 | 9.17 | 33.97 | 17.55 | 18.15 | 12,770; 23,745 | 0.000 |
| 3.5% discount p.a. | 14.75 | 7.95 | 32.86 | 14.83 | 18,076 | 13,416; 22,922 | 0.000 |
| 3.0% discount p.a. | 14.88 | 8.1 | 32.13 | 15.18 | 17.25 | 12,551; 21,946 | 0.000 |
| mean total costs (adjusted Lin1) | |||||||
| adjusted (3 monthly intervals) | 16.16 | 38.98 | 22.82 | ||||
| adjusted annually | 12.11 | 36.71 | 24.6 | ||||
| 3.5% discount p.a. | 11.68 | 33.71 | 22.03 | ||||
| 3.0% discount p.a. | 11.74 | 34.09 | 22.35 | ||||