Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 6;7:288. doi: 10.1186/s40425-019-0778-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Poly(I:C)_c triggers transcriptional reprogramming of MDSC. Mice with orthotopic T110299 tumors were treated twice with poly(I:C)_c prior to sacrifice as described before. RNA of MDSC populations was isolated for whole transcriptome analysis. a Principal component analysis (PCA) of transcriptome of splenic or tumor-derived MDSC with and without poly(I:C)_c treatment. b Heatmap of gene expression values (colors indicate row z-scores) for the 1.000 genes contributing most to principle component 2 (PC2). c DAVID analysis for enriched gene ontology biological processes (GO:BP) terms from differentially expressed genes (adjusted p < 0.001, ≥ 2-fold change) upon poly(I:C)_c treatment from splenic MDSC. d Gene set enrichment analysis (GSEA) of differentially expressed genes upon poly(I:C)_c treatment compared to published gene sets describing PMN-MDSC vs. neutrophils (GSE24102) and macrophage polarization (GSE5099). Data shown for n = 3 to 4 mice per group