Table 1.
Clinical characteristics of patients with ICIs induced endocrine toxicity
| Endocrine AEs in ICIs (6260) | Endocrine AEs in other drugs (233338) | |
|---|---|---|
| Gender | ||
| Male | 3428(54.76) | 106,643(45.70) |
| Female | 2095(33.47) | 95,425(40.90) |
| Missing | 737(11.77) | 31,270(13.40) |
| Age | ||
| < 65 | 2481(39.63) | 91,368(39.16) |
| > =65 | 2496(39.87) | 55,099(23.61) |
| Missing | 1283(20.50) | 86,871(37.23) |
| Year | ||
| 2014 | 116(1.85) | 17,308(7.42) |
| 2015 | 59(0.94) | 37,813(16.21) |
| 2016 | 944(15.08) | 47,013(20.15) |
| 2017 | 1572(25.11) | 62,480(26.78) |
| 2018 | 2838 (45.34) | 55,743(23.89) |
| 2019Q1 | 731(11.68) | 12,981(5.56) |
| Outcome | ||
| Death | 601(9.60) | 9752(4.18) |
| Life-threatening | 474(7.57) | 10,435(4.47) |
| Disability | 108(1.73) | 4958(2.12) |
| Hospitalization | 2329(37.20) | 69,842(29.93) |
| Congenital anomaly | 0(0.00) | 102(0.04) |
| Other serious | 1605(25.64) | 78,742(33.75) |
| Required intervention | 1(0.02) | 50(0.02) |
| Missing | 1142(18.24) | 59,457(25.48) |
| Report countries | ||
| United States | 1997(31.90) | 124,384(53.31) |
| Japan | 1748(27.92) | 14,146(6.06) |
| Great Britain | 181(2.89) | 11,376(4.88) |
| France | 393(6.28) | 10,258(4.40) |
| Canada | 62(0.99) | 8741(3.75) |
| Italy | 116(1.85) | 7922(3.40) |
| Other countries | 1033(16.50) | 43,567(18.67) |
| Missing | 730(11.66) | 12,944(5.55) |