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. 2019 Nov 6;19:298. doi: 10.1186/s12906-019-2695-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Antiviral effects of the compounds derived from the Pg- YP-I-22C fraction on some steps of the DENV replication cycle. The cells were treated with the compounds for 48 h and then infected with DENV (MOI = 1). This infection strategy (pre-treatment) is represented by the dark bars. In addition, independent cell cultures were infected with DENV (MOI = 1) and then treated with the compounds (post-treatment strategy; indicated by clear bars). The error bars correspond to the SEM. The asterisks indicate cases with statistically significant differences (Student’s t-test; p < 0.05) in relation to the control without treatment