Table 2.

Multivariate analysis of PFS and OS

	PFS			OS
	HR	95%CI	P value	HR	95%CI	P value
Age > 60	1.63	0.81–3.26	0.17	2.23	1.07–4.65	0.03
Female	1.31	0.28–6.16	0.73	2.32	0.37–14.36	0.36
Smoking	1.49	0.53–4.22	0.45	1.96	0.61–6.31	0.26
PS Score 0–1	0.32	0.09–1.10	0.07	1.07	0.23–4.89	0.93
Extensive Stage	2.03	0.91–4.57	0.08	2.70	1.12–6.47	0.03
TMB > 21 mutations/Mb	0.27	0.11–0.66	0.004	0.17	0.06–0.44	0.0003