Table 2.
Correlation between the factors and clinicopathologic characteristics in HCC in TCGA dataset (n = 363)
| Clinical features | Case | RAD52 level (RSEM; mean ± SD) | P value |
|---|---|---|---|
| Sample | |||
| LIHC | 363 | 6.4606 ± 0.6778 | P < 0.05* |
| Normal | 50 | 6.0250 ± 0.5742 | |
| Age at diagnosis (years) | |||
| > 45 | 314 | 6.4371 ± 0.6918 | P > 0.05 |
| ≤ 45 | 48 | 6.6329 ± 0.5475 | |
| Unknown | 1 | ||
| Gender | |||
| Male | 246 | 6.3721 ± 0.6948 | P < 0.05* |
| Female | 117 | 6.6466 ± 0.6020 | |
| The AFP in serum | |||
| > 20 ng/ml | 129 | 6.5403 ± 0.6778 | P > 0.05 |
| ≤ 20 ng/ml | 143 | 6.4050 ± 0.6319 | |
| Unknown | 91 | ||
| Clinical stage | |||
| I–II | 251 | 6.4353 ± 0.6493 | P > 0.05 |
| III–IV | 88 | 6.5033 ± 0.7782 | |
| Unknown | 24 | ||
| Child–Pugh classification | |||
| A | 213 | 6.4195 ± 0.7080 | P > 0.05 |
| B | 21 | 6.4685 ± 0.5537 | |
| C | 1 | ||
| Unknown | 128 | ||
| HBsAg infection | |||
| Yes | 226 | 6.4981 ± 0.6733 | P > 0.05 |
| No | 122 | 6.4139 ± 0.6543 | |
| Unknown | 15 | ||
| Lymph node | |||
| N0 | 246 | 6.4788 ± 0.6713 | P > 0.05 |
| N1 | 3 | 6.8001 ± 1.0916 | |
| Unknown | 114 | ||
| Metastasis | |||
| M0 | 260 | 6.4512 ± 0.6827 | P > 0.05 |
| M1 | 4 | 6.0975 ± 0.5427 | |
| Unknown | 99 | ||
TCGA The Cancer Genome Atlas, LIHC liver hepatocellular carcinoma, HCC hepatocellular carcinoma, RSEM RNA-seq by expectation-maximization, RAD52 radiation sensitive 52, AFP alpha fetoprotein, HBsAg hepatitis B surface antigen, SD standard deviation
* P < 0.05