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. 2019 Nov 6;20:815. doi: 10.1186/s12864-019-6147-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Interpretation of our results – description of processes during embryonic wound healing. NO release appears very early after injury. The level of NO is the highest at 15 minutes pw and the physiological level is restored at 30 minutes pw (early phase of healing). De novo expression of injury response genes starts shortly after injury and the level of expression is the highest 30 minutes pw. Level of expression of injury response genes is restored to physiological level 90 minutes pw. De novo expression of interesting NO dependent candidate lep and remodelling factors starts around 30 minutes pw. At the same time around 80 % of injury is already closed (middle phase of healing). The injury is closed 90 minutes pw and remodelling phase is initiated. Cell migration appears and the expression of remodelling factors changes (late phase of healing)