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. 2019 Nov 7;38:456. doi: 10.1186/s13046-019-1463-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic diagram of the molecular mechanisms underlying NOTCH2-regulated EMT. In NPC cells, NOTCH2 interacts with TRAF6; however, NOTCH2 expression is dramatically reduced upon carcinogenic factor stimulus. TRAF6 activates the non-canonical AKT pathway. AKT activation leads to the induction of vimentin and repression of E-cadherin, which are necessary for cancer cell EMT and migration