Table 1.
The risk of 5-year mortality by 8q24.3 copy number alteration—categorized by anatomical location of each cancer—and expressed as odds ratios [OR] and 95% confidence intervals [CI]
| Total | Model 1*(n = 9568) | Model 2** (n = 7593) | Model 3*** (n = 4110) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % died | % diploid | n | Deletions (− 1 or − 2) | Gain (+ 1) | Amplification (≥ + 2) | Deletions (− 1 or − 2) | Gain (+ 1) | Amplification (≥ + 2) | Deletions (− 1 or − 2) | Gain (+ 1) | Amplification (≥ + 2) | |
| Adrenal glands | 1.8 | 79.8 | 109 | 8.60 [0.5–148.39] | ||||||||
| Bladder | 44.8 | 39.1 | 87 | 0.75 [0.31–1.84] | ||||||||
| Blood | 56.3 | 83.2 | 238 | 0.87 [0.42–1.80] | ||||||||
| Brain | 51.4 | 80.2 | 1,02 | 1.65 [0.94–2.90] | 0.84 [0.56–1.24] | 0.27 [0.12–0.60] | 1.23 [0.79–1.92] | 0.83 [0.43–1.59] | 0.68 [0.37–1.25] | |||
| Breast | 18.6 | 56.0 | 1272 | 1.17 [0.55–2.50] | 1.05 [0.72–1.52] | 1.31 [0.92–1.86] | ||||||
| Cervical | 19.9 | 52.5 | 276 | 0.78 [0.21–2.88] | 1.25 [0.68–2.32] | |||||||
| Colorectal | 18.9 | 38.0 | 513 | 3.64 [1.31–10.17] | 1.51 [0.93–2.46] | 0.90 [0.25–3.25] | 4.12 [1.15–14.82] | 1.75 [1.32–2.31] | 0.78 [0.23–2.64] | |||
| Esophagus | 38.4 | 25.2 | 159 | 1.16 [0.32–4.23] | 1.32 [0.60–2.88] | 0.93 [0.32–2.70] | ||||||
| Eyes | 26.7 | 24.0 | 75 | 9.38 [1.14–77.14] | 5.67 [0.51–62.66] | |||||||
| Head and neck | 39.1 | 27.8 | 468 | 1.35 [0.88–2.09] | 2.23 [1.10–4.51] | 1.40 [0.75–2.62] | 2.68 [2.17–3.30] | |||||
| Kidney | 23.0 | 77.6 | 738 | 0.49 [0.22–1.11] | 1.83 [1.17–2.87] | 0.41 [0.21–0.82] | 1.70 [0.73–3.96] | 0.52 [0.31–0.85] | 0.60 [0.23–1.62] | |||
| Liver | 32.6 | 31.9 | 313 | 1.49 [0.52–4.26] | 0.90 [0.52–1.57] | 1.31 [0.66–2.61] | ||||||
| Lung | 33.7 | 32.8 | 811 | 1.49 [0.76–2.90] | 1.70 [1.22–2.36] | 0.76 [0.37–1.56] | 1.97 [1.02–3.80] | 1.76 [1.24–2.51] | 0.80 [0.44–1.46] | 1.24 [0.34–4.51] | 1.77 [1.06–2.97] | 0.40 [0.10–1.65] |
| Mesenchyme | 33.5 | 55.1 | 185 | 1.47 [0.60–3.56] | 1.91 [0.94–3.89] | |||||||
| Mesothelium | 81.3 | 73.3 | 75 | 1.08 [0.26–4.48] | ||||||||
| Ovarian | 47.5 | 16.1 | 503 | 1.81 [0.83–3.94] | 1.35 [0.81–2.27] | 1.01 [0.60–1.72] | 1.83 [1.39–2.41] | 1.53 [1.15–2.05] | 1.33 [0.91–1.93] | 1.52 [1.26–1.83] | 7.24 [6.44–8.13] | 9.73 [7.19–13.16] |
| Pancreas | 55.8 | 60.4 | 154 | 1.87 [0.88–4.01] | 1.69 [0.53–5.42] | |||||||
| Prostate | 0.9 | 57.7 | 647 | 5.61 [0.56–56.12] | 0.68 [0.07–6.56] | 1.84 [0.19–17.96] | 24.75 [0.8–765] | 1.12 [0.76–1.64] | 4.41 [3.41–5.71] | |||
| Skin | 31.6 | 42.1 | 335 | 1.22 [0.48–3.11] | 0.91 [0.56–1.50] | 1.22 [0.48–3.11] | ||||||
| Stomach | 36.3 | 34.8 | 397 | 0.91 [0.33–2.53] | 0.60 [0.39–0.93] | 0.70 [0.26–1.86] | 0.93 [0.13–6.52] | 0.60 [0.37–0.98] | 0.56 [0.36–0.87] | |||
| Testicle | 1.6 | 19.2 | 125 | |||||||||
| Thymus | 5.3 | 89.4 | 113 | |||||||||
| Thyroid | 2.4 | 97.4 | 464 | |||||||||
| Uterus | 18.1 | 60.7 | 491 | 4.31 [1.70–10.88] | 3.53 [2.11–5.90] | 4.31 [1.62–11.48] | 4.84 [2.75–8.51] | 3.67 [2.03–6.66] | 4.58 [1.43–14.6] | 1.13 [0.16–7.78] | 1.99 [1.28–3.08] | 2.08 [0.06–75.09] |
| Total | 28.3 | 54.1 | 9568 | 1.42 [1.16–1.73] | 1.31 [1.19–1.45] | 1.20 [1.02–1.40] | 1.37 [0.88–2.15] | 1.31 [0.78–2.20] | 1.41 [0.76–2.61] | 1.23 [0.69–2.16] | 1.98 [1.22–3.21] | 2.19 [1.13–4.26] |
*Model 1 is unadjusted for any confounders
**Model 2 is adjusted for age, sex, calendar period, and clustering by study
***Model 3 is additionally adjusted for interaction with tumor stage and confounding by HSF1