Table 1.

Descriptions of the 12 federated queries across OMA, Bgee, UniProt used for evaluating our system; the queries can be further refined and executed through our template search interface available at http://biosoda.expasy.org/

Query	Description
Q1	Proteins in OMA encoded by the INS gene and their evidence type from UniProt.
Q2	Rabbit proteins encoded by genes orthologous to the HBB-Y gene in mouse and their associated information from UniProt.
Q3	Rattus norvegicus proteins paralogous to Tp53 and their UniProt function annotations.
Q4	Mouse genes expressed in the liver that are orthologous to the human INS gene.
Q5	Genes orthologous to a gene expressed in the fruit fly brain.
Q6	Genes in primates orthologous to a gene expressed in the fruit fly brain.
Q7	Anatomic entities where the ins zebrafish gene is expressed and the ins gene GO annotations.
Q8	Genes expressed in the human pancreas and their annotation in UniProt.
Q9	Genes expressed in the human brain during the infant stage and their UniProt disease annotation.
Q10	The orthologs of a gene that is expressed in the fruit fly brain and the UniProt annotations of these orthologs.
Q11	The orthologs in primates of a gene that is expressed in the fruit fly brain, and the UniProt annotations of the primate orthologs.
Q12	Proteins in humans, with a disease annotation, that are orthologous to a gene expressed in the rat brain.