Kaplan–Meier plot of time to deterioration in EORTC QLQ-C30 global health status/quality of life at progression. bid, twice daily; CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module; HR, hazard ratio; NC, not calculable; QoL, quality of life; TPC, treatment of physician's choice. Deterioration was defined as the onset of a ≥10-point decrease in global health status/QoL score from baseline. Patients whose global health status/QoL score did not show a clinically important deterioration and who were alive at the time of analysis, or who experienced deterioration in global health status/QoL or death after two or more missed assessments, were censored at the latest evaluable EORTC QLQ-C30 assessment.