Kaplan–Meier estimates of time to deterioration for EORTC QLQ-C30 functional subscales before or at progression. (a) Physical; (b) role; (c) social; (d) cognitive and (e) emotional. bid, twice daily; CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module; HR, hazard ratio; NC, not calculable; TPC, treatment of physician's choice.