Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov;29(11):1860–1877. doi: 10.1101/gr.234435.118

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Malikic et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Figure 1. — Comparison of PhISCS with SiFit based on the (normalized) Robinson-Foulds distance. (A) Results for the case where ISA violations are allowed in PhISCS (SiFit, by default accounts for possible ISA violations), but only SCS data is used as the input. (B) Results for the case where ISA violations are allowed in PhISCS and both single-cell and bulk data (with coverage 10,000×) used as its input (SiFit does not support the use of bulk data). In all simulations, 100 single cells were sampled from 10 subclones harboring a total of 40 mutations. Only one bulk sample was used in B, potentially limiting the relative advantage of PhISCS by its use of bulk data. Nevertheless, the normalized RF distance between PhISCS inferred tree and the ground truth is reduced by the use of bulk data in all settings. (Note that “ISA” on the x-axes denotes the number of simulated ISA violating mutations.)