Figure 1.

Overview of SiCloneFit Model. (A) From an observed noisy genotype matrix of single cells, SiCloneFit infers the clonal clusters, clonal phylogeny, and clonal genotypes of single cells. (B) A probabilistic graphical model representing the singlet model of SiCloneFit. Shaded nodes represent the observed values or fixed parameters; unshaded nodes are the latent variables that are of interest; a posterior distribution over the values of the unshaded nodes is approximated using samples from the proposed Gibbs sampler. The variables and indices are described in Supplemental Methods. (C) Distributional assumptions for the different variables in the SiCloneFit singlet model.