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. 2019 Nov;29(11):1910–1918. doi: 10.1101/gr.250019.119

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© 2019 Shohat and Shifman; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — A genome-wide CRISPR screen to identify genes essential in mESCs. (A) Schematic overview of the genome-wide CRISPR screen. (B) A volcano plot of the screen results. Significance (−log₁₀ of the P-value) across all days as a function of the average fold change for each gene at the end of the screen. Colors indicate the density of the points. The red line represents a corrected P < 0.05. (C) Venn diagram presenting the overlap between essential genes in the current screen and essential genes in a previous study (Tzelepis et al. 2016). (D) The distribution of the average fold change per gene (day 15) was drawn separately for genes with significant evidence for negative selection in a previous study (Tzelepis et al. 2016) (blue) and genes with no significant evidence for selection (orange).