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. 2019 Nov;29(11):1910–1918. doi: 10.1101/gr.250019.119

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© 2019 Shohat and Shifman; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Gene essentiality as a quantitative phenotype. (A,B) Two different dynamics of gRNA depletion rates (see Supplemental Fig. S3A for clustering results). (A) Fast-declining cluster, and (B) gradual-declining cluster. For each gene the gRNA with the strongest decline is shown (black lines). The red line indicates the trend of all genes in the cluster. (C) Expression in mESCs of genes in the fast- and gradual-declining groups. Expression values are probe signal intensities (log₁₀) from microarray data. (D) Percentage of genes with at least one paralog gene. (*) P < 0.05; (***) P < 0.001.