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. 2019 Nov;29(11):1910–1918. doi: 10.1101/gr.250019.119

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© 2019 Shohat and Shifman; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Overlap between essential genes in mESCs and genes essential in vivo in mouse or human. (A) Overlap between essential genes in mESCs and embryonic lethal genes in mice (odds ratio = 12.84, P < 10⁻¹⁶) and with genes known to be lethal or cause abnormal growth (odds ratio = 13.94, P < 10⁻¹⁶). (B) Overlap between human LoF mutation-intolerant genes, essential genes in mESCs (odds ratio = 1.88, P < 10⁻¹⁶), and essential genes in hESCs (odds ratio = 2.33, P < 10⁻¹⁶). (C) Expression levels in mESCs for genes intolerant to LoF mutations in human divided into essential and nonessential genes in ESCs. Expression values are signal intensities (log₁₀) from microarray data. (D) Association between the pattern of expression (brain-specific genes vs. globally expressed genes) and being essential in ESCs and/or intolerant to LoF mutations in human. Values are odds ratio ± 95% confidence interval. (E) Association between dominant and recessive inheritance and being essential in ESCs and/or intolerant to LoF mutations in humans. Values are odds ratio ± 95% confidence interval. (***) P < 0.001.