Table 2. In vitro antimalarial activity and yield of alkylated thiosalicylic acid derivatives and of 1,2,3-triazolyl thiosalicylic acid derivatives.

Entry	Cmpd	R	Yield (%)	P. falciparum a IC50 μM	Z value	R 2
1	1	Propargyl	81	>200
2	1a	Cyclohexyl	87	>200
3	1b	Benzyl	73	>200
4	1c	3-Phenyl-propyl	75	>200
5	1d	Cinnamyl	68	>200
6	1e	Octyl	83	>200
7	1f	Decyl	81	>200
8	1g	CH2CH2CO2CH2CH3	78	>200
9	1h	Prenyl	72	>200
10	1i	Geranyl	88	>200
11	1j	Farnesyl (Salirasib)	79	20.34 ± 5.52	0.93 ± 0.06	0.95 ± 0.02
12	1k	Phytyl	85	13.40 ± 1.53	0.93 ± 0.06	0.98 ± 0.02
13	2a	Cyclohexyl	84	>200
14	2b	Benzyl	80	>200
15	2c	3-Phenyl-propyl	88	>200
16	2d	Cinnamyl	86	65.33 ± 10.71	0.89 ± 0.09	0.87 ± 0.01
17	2e	Octyl	78	>200
18	2f	Decyl	88	>200
19	2g	CH2CH2CO2CH2CH3	91	>200
20	2h	Prenyl	89	>200
21	2i	Geranyl	84	>200
22	2j	Farnesyl	90	25.97 ± 1.32	0.94 ± 0.06	0.96 ± 0.02
23	2k	Phytyl	83	9.75 ± 1.97	0.92 ± 0.06	0.98 ± 0.01
24	2l	CH2CO2CH2CH3	92	>200
25	2m	Cetyl	81	14.44 ± 5.43	0.93 ± 0.06	0.97 ± 0.01
26	2n	Tridecanyl	55	19.83 ± 5.14	0.88 ± 0.08	0.97 ± 0.02
27	2o	2-Phenyl-ethyl	94	>200
28	2p	2-Naphthylmethyl	33	20.54 ± 5.45	0.92 ± 0.06	0.96 ± 0.04
	CQ			8.15 ± 1.83 nM	0.75 ± 0.18	0.96 ± 0.02
	ART			1.64 ± 0.08 nM	0.86 ± 0.11	0.96 ± 0.03

^aEvaluated by the NanoLuc luciferase method.