| Gastrointestinal effects |
Sparfloxacin, grepafloxacin |
>10% |
| Others |
2–8% |
| Arthralgia effects |
Sprafloxacin, levofloxacin, grepafloxacin ≫ others |
0.5–2% |
| CNS effects |
Trovafloxacin |
2–11% dizziness |
| Levofloxacin |
0.026% confusion, alteration in mentation and effect |
| Phototoxicity |
Clinafloxacin, sparfloxacin |
>10% |
| Others |
<2.5% |
| Genotoxicity |
Lomefloxacin, moxifloxacin, ciprofloxacin |
|
| QTc prolongation |
Grepafloxacin, sparfloxacin |
2.9% |
| Haematological effect |
Temafloxacin |
0.02% thrombocytopenia, haemolysis, and renal failure |
| Hepatic eosinophilia effect |
Trovafloxacin |
0.006% |
| Grepafloxacin |
12–16% transaminase elevation |
| Others |
<3% |
| Pulmonary interstitial eosinophilia |
Gemifloxacin |
|
| Immunological side effect |
Gemifloxacin |
|
| Hypoglycaemia |
Clinafloxacin, gatifloxacin |
|
| CYP 450 inhibition |
Enoxacin, clinafloxacin > ciprofloxacin > lomefloxacin, ofloxacin > levofloxacin, sparfloxacin, gatifloxacin, moxifloxacin |
|
